Startup israelí espera combatir el alzheimer con medicamento que destruye enzimas dañinas

La israelí ProteKt Therapeutics está desarrollando un medicamento para tratar las primeras etapas del Alzheimer mediante el uso de una enzima que se cree que contribuye al desarrollo de la enfermedad neurodegenerativa que causa la pérdida de la memoria.

La empresa espera que al inhibir la enzima, logre mejorar las funciones cognitivas de los pacientes y frenar el avance de la enfermedad. El mismo tratamiento podría beneficiar a pacientes con otras enfermedades neurodegenerativas como la esclerosis lateral amiotrófica (ELA), Huntington y Parkinson, reportó el sitio The Times of Israel.

ProteKt Therapeutics fue fundada por la Corporación Económica de la Universidad de Haifa y el Fondo de Innovaciones Carmel, basada en la investigación del profesor Kobi Rosenblum de la Universidad de Haifa y formó parte de la incubadora biotecnológica FutuRx.

“En los trabajos de investigación realizados por el profesor Kobi Rosenblum, y otros científicos, se descubrió que la inhibición de esta enzima, llamada PKR, puede mejorar las funciones cognitivas”, indicó Yotam Nisemblat, director general de la empresa ubicada en Ness Ziona.

“Todos tenemos la enzima, pero se encontró que las personas con Alzheimer tienen niveles elevados, o “sobreactivación”, de PKR. Su inhibición puede devolverla a su nivel normal”, explicó.

Yotam Nisemblat, CEO de ProteKt Therapeutics (Cortesía)

ProteKt ha identificado 150 compuestos sintéticos pequeños que podrían ayudar a inhibir la enzima a través de un proceso robótico y computarizado para examinar millones de moléculas.

“Identificamos varias moléculas que podrían ser inhibidores de la enzima”, dijo Nisemblat. “Demostramos que los compuestos son efectivos en modelos de Alzheimer en el laboratorio”.

Se descubrió que los compuestos pueden reducir los marcadores neuroinflamatorios típicos del Alzheimer y proteger a las neuronas de las toxinas del beta amiloide, un péptido de 36 a 43 aminoácidos, el principal componente de las placas amiloides que se encuentran en los cerebros de las personas con Alzheimer.

“Los compuestos también pueden mejorar la funcionalidad neuronal de las células, lo que indica su potencial de mejorar la cognición”, enfatizó.

En noviembre, la empresa anunció que había recaudado 3.6 millones de dólares de inversorsionistas, entre ellos el fondo Fonds de solidarité FTQ de Quebec y la empresa farmacéutica coreana Bukwang Pharmaceutical, que se unieron a FutuRx, OrbiMed, Johnson & Johnson Innovation – JJDC, Inc., Takeda Ventures, Inc. y RM Global Partners (RMGP) BioPharma Investment Fund para una participación en la empresa.

Los ingresos de la financiación se utilizarán principalmente para ayudar a la empresa a reducir el grupo que había seleccionado e identificar la molécula más eficaz, mejorarla y asegurarse de que sea “selectiva, estable y soluble” para el desarrollo de un medicamento.

La empresa también espera demostrar la efectividad del compuesto en animales y su capacidad de ingresar al cerebro a través del torrente sanguíneo cruzando la barrera hematoencefálica, una frontera semipermeable que separa la sangre circulante del cerebro y otros fluidos del sistema nervioso central.

“Los tratamientos tradicionales no son beneficiosos”, señaló Nisemblat. “Creemos que nuestro nuevo método podrá frenar el avance del Alzheimer y detener el deterioro de los pacientes.

“El desarrollo llevará algún tiempo, ya que estamos sólo al principio del proceso, pero creemos que el mecanismo de PKR tendrá un efecto significativo en el avance y la magnitud de la enfermedad”.

“La financiación también permitirá a la empresa llegar a una etapa de desarrollo, tras la cual podrá recaudar fondos adicionales para realizar ensayos clínicos con pacientes”, concluyó.

Fuente: Enlace Judío

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