COVID-19/Israel: cinco pacientes graves curados con un remedio experimental

el remedio experimental Allocetra
el remedio experimental Allocetra

El 1 de octubre pasado el último de los cinco pacientes con COVID-19 en terapia intensiva que recibieron el remedio experimental Allocetra fue dado de alta del Centro Médico Universitario Hadassah en Jerusalén.

Un ensayo clínico mostró el potencial de Allocetra, un nuevo fármaco de Enlivex de Israel diseñado a partir de células de donantes humanos sanos.

Este fue el resultado exitoso del primer ensayo clínico mundial de Allocetra. Lo realizó la compañía de inmunoterapia en etapa clínica Envilex Therapeutics.
El remedio se creó a partir de células humanas donadas por personas sanas.

Los cinco pacientes salieron de la clínica donde estaban internados una semana después de recibir Allocetra y dar negativo en las pruebas de coronavirus. Además no se informó de efectos adversos graves relacionados con el fármaco a la vez que el tratamiento fue bien tolerado.

El fármaco Allocetra se desarrolló sobre la base de la investigación del director médico y científico de Enlivex, el doctor Dror Mevorach. Es el jefe de medicina interna y de una de las salas de coronavirus del Hadassah.

Coronavirus: Argentina es el único país que supera a Israel en tasa de mortalidad

En julio incluimos Enlivex como uno de los 13 prometedores tratamientos emergentes contra el COVID-19 de Israel. Este nuevo medicamento de inmunoterapia trata la disfunción y la insuficiencia orgánicas múltiple aguda asociada con la sepsis y el COVID-19. También en los tumores sólidos, al reequilibrar el sistema inmunológico después de una tormenta de citocinas.

“Ya tratamos a 15 pacientes con Allocetra en nuestro hospital. De ellos, hay 10 con sepsis y cinco con coronavirus”. Lo afirmó el investigador principal, el doctor Vernon van Heerden, jefe de cuidados intensivos en Hadassah.

El científico añadió que “si nos basamos en los convincentes resultados preliminares que demostraron la seguridad y una indicación de la eficacia de Allocetra en estos pacientes complicados, el producto de Enlivex tiene el potencial de beneficiar a los pacientes de COVID-19 en condiciones graves o críticas”.

A su vez, Mevorach remarcó que “creemos que los resultados del tratamiento con Allocetra en estos pacientes graves y críticos con coronavirus representan una oportunidad única para que Enlivex contribuya a los esfuerzos encaminados a combatir la pandemia mundial actual”.

A principios de 2020, Hadassah trató a 12 pacientes con COVID-19 con inmunoglobulina experimental derivada del plasma rico en anticuerpos de pacientes recuperados. El suero, preparado por la compañía biofarmacéutica Kamada condujo a una mejora en 11 de los 12 pacientes en 24 y 48 horas, y los 11 se fueron de alta unos días después.

Sin embargo, el medicamento de Kamada se destinó a pacientes moderados de coronavirus mientras que Allocetra se pensó para casos graves o críticos.

Enlivex cree que, si se aprueba Allocetra, se cubre la brecha que existe actualmente en el tratamiento de pacientes con COVID-19 en estado de gravedad. La empresa planea un ensayo clínico de fase 2 más grande que se encuentra sujeto a una aprobación regulatoria. Israel21C vía Aurora

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