Descubren en Israel nuevos remedios contra el Parkinson

Israel-El-descubrimiento-de-nuevos-farmacos-para-la-enfermedad-de-Parkinson-ilusiona-la-promesa-de-impedir-la-progresion-de-la-enfermedad- Vis a Vis
Israel-El-descubrimiento-de-nuevos-farmacos-para-la-enfermedad-de-Parkinson-ilusiona-la-promesa-de-impedir-la-progresion-de-la-enfermedad- Vis a Vis

El descubrimiento de nuevos fármacos para la enfermedad de Parkinson ilusiona la promesa de impedir la progresión de la enfermedad.

Investigadores de Israel han descubierto que las proteínas llamadas BMP5 / 7 son nuevas terapias potenciales (y prometedoras) para combatir la enfermedad de Parkinson. Se piensa que podrían cambiar la trayectoria del trastorno. Estos hallazgos se publicaron recientemente en la prestigiosa revista de neurología clínica Brain.

La enfermedad de Parkinson afecta a más de 10 millones de personas en todo el mundo. Se caracteriza por la degeneración progresiva de las células cerebrales secretoras de dopamina que provoca graves alteraciones del movimiento.

Hoy en día, se cree que la proteína alfa-sinucleína, que está presente en todos los cerebros humanos, juega un papel central en el desarrollo de la enfermedad de Parkinson al plegarse mal y formar grumos tóxicos en las células cerebrales secretoras de dopamina de los individuos afectados.

Actualmente, todas las terapias utilizadas para la enfermedad de Parkinson mejoran los síntomas.

Sin embargo, su eficacia es inaceptablemente baja en las etapas avanzadas de la enfermedad y lamentablemente, no detienen ni ralentizan la progresión de la enfermedad.

El Dr. Claude Brodski, MD y su equipo descubrieron que en las células cerebrales productoras de dopamina de pacientes con enfermedad de Parkinson, la señalización de BMP5 / 7 se redujo significativamente.

Leer más: Investigadores israelíes descubren un medicamento “natural” para tratar la osteoporosis.

Es un cambio que posiblemente podría contribuir al desarrollo de la enfermedad. Para estudiar esta posibilidad, los científicos diseñaron genéticamente cerebros de ratones para reducir la señalización de BMP5 / 7 en las células cerebrales productoras de dopamina.

Confirmando su sospecha, la reducción de la señalización de BMP5 / 7 de hecho conduce a una acumulación de grupos tóxicos de alfa-sinucleína y pérdida de células cerebrales productoras de dopamina.

Luego, los investigadores plantearon la hipótesis de que si la falta de señalización de BMP5 / 7 provoca la pérdida de células cerebrales productoras de dopamina, la administración de BMP5 / 7 podría proteger estas células en un modelo de enfermedad de Parkinson.

“De hecho, descubrimos que el tratamiento con BMP5 / 7 puede, en un modelo de ratón con enfermedad de Parkinson, prevenir de manera eficiente la acumulación de alfa-sinucleína, la pérdida de células cerebrales productoras de dopamina y las alteraciones del movimiento asociadas.

Estos hallazgos son muy interesantes, ya que sugieren que BMP5 / 7 podría ralentizar o detener la progresión de la enfermedad de Parkinson.

Actualmente, estamos centrando todos nuestros esfuerzos en acercar nuestro descubrimiento a la aplicación clínica ”, dice el Dr. Brodski.

El Dr. Galit Mazooz Perlmuter, dijo: “existe una gran necesidad insatisfecha de nuevas terapias para tratar la enfermedad de Parkinson. Especialmente en las etapas avanzadas de la enfermedad. Los hallazgos del Dr. Brodski, aunque en las primeras etapas, ofrecen un objetivo farmacológico para la enfermedad que abordará el mecanismo de esta condición devastadora. Ahora estamos buscando un socio industrial para un mayor desarrollo de esta invención pendiente de patente”.

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