Consideran en Israel cuarta dosis de vacuna para pacientes inmunodeprimidos

Consideran en Israel cuarta dosis de vacuna para pacientes inmunodeprimindos
Consideran en Israel cuarta dosis de vacuna para pacientes inmunodeprimindos

El panel que asesora al Ministerio de Salud de Israel sobre la pandemia de coronavirus discutirá la posibilidad de administrar una cuarta dosis de vacuna contra COVID-19 a pacientes inmunodeprimidos, según Enlace Judío.

En meses anteriores, varios estudios mostraron que ciertas categorías de pacientes con un sistema inmunológico debilitado, como los receptores de trasplantes, tenían muchas menos probabilidades de desarrollar anticuerpos después de 2 dosis que la población general.

Si bien la investigación mostró que el refuerzo en general mejoró la situación, esto no fue así para todas las personas inmunodeprimidas.

Por ejemplo, un estudio realizado en agosto por el Centro Médico Rabin en Petah Tikva y el servicio de salud Clalit mostró que entre los receptores de trasplantes de pulmón, el 33% desarrolló anticuerpos después del refuerzo, en comparación con el 18% después de las dos primeras inyecciones.

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Para los receptores de trasplantes de corazón, las tasas fueron del 58% después de la tercera inyección y del 31% después de la segunda. Entre los receptores de trasplante de hígado, el 71% desarrolló anticuerpos después de la tercera inyección, en comparación con el 47% después de la segunda.

El panel asesor debatirá la opción de una cuarta vacuna a finales de esta semana.

Según el profesor Cyrille Cohen, director del laboratorio de inmunología de la Universidad de Bar-Ilan, la medida tiene sentido.

“Sabemos que las personas con un sistema inmunológico funcional necesitan tres dosis”, dijo Cohen. “Los pacientes inmunodeprimidos recibieron su tercera vacuna hace casi 6 meses, por lo que no es una mala idea ofrecerles otro refuerzo, ya que tienen un alto riesgo”.

Según el científico, es difícil saber si va a ayudar.

“Es muy complejo responder la pregunta sin realmente realizar el procedimiento”, dijo. “Vimos cómo con la tercera vacuna muchos se mostraron escépticos cuando Israel comenzó a administrarla, y ahora la mayor parte del mundo está de acuerdo en que es necesaria”.

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El elemento crucial a considerar es si una cuarta dosis sería segura.

Según Cohen, dado que la mayoría de los efectos secundarios asociados con la vacuna Pfizer están conectados de alguna manera con una reacción exagerada del sistema inmunológico, la inyección adicional no debería ser un problema para los pacientes cuyo sistema no reacciona con la suficiente fuerza.

“La mayoría de los efectos secundarios que hemos visto están asociados con la inflamación o los síndromes autoinmunes. Es menos probable que estos pacientes los desarrollen”, dijo.

El profesor también señaló que, como sucedió con la tercera dosis, no todos los pacientes inmunosuprimidos deben ser considerados de la misma manera.

“Hay una diferencia entre, por ejemplo, los receptores de trasplantes, cuyo sistema inmunológico está debilitado a propósito, y los pacientes con cáncer. Su sistema inmunológico a veces se debilita como efecto secundario del tratamiento”, dijo Cohen.

En julio, el Ministerio de Salud comenzó a administrar vacunas de refuerzo a categorías específicas de pacientes.

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Por ejemplo, los pacientes con cáncer que padecían tumores sólidos como cáncer de mama, pulmón o colon no calificaban. Las personas con enfermedades reumatológicas o autoinmunes que estaban siendo tratadas con medicamentos específicos no calificaron según el ministerio. Tampoco aquellas con ciertas neoplasias hematológicas y receptores de trasplantes de corazón, pulmón, riñón o hígado.

Cuando se le preguntó si la idea de una cuarta dosis podría debilitar la confianza del público en la vacunación, Cohen dijo que era importante recordar que no todas las vacunas son iguales. No es inusual que algunas de ellas se administren de manera regular.

“Hay algunas vacunas que son muy eficientes, como las contra las enfermedades infantiles”, dijo. “Otros que son buenos para prevenir enfermedades graves pero no tan efectivos para prevenir infecciones. Hay vacunas que se deben administrar todos los años, como la de la influenza», agregó.

“Creo que eventualmente, una combinación entre vacunas y exposición natural nos ayudará a hacer que el coronavirus sea menos amenazante”, dijo Cohen. “Por el momento, las vacunas son la mejor manera de luchar contra la pandemia y tenemos que estar agradecidos por eso”, sentenció.

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