Hospital israelí desarrolla tratamiento contra la esclerosis múltiple

Israel amplía su ayuda con Honduras y Guatemala tras los huracanes de las últimas semanas
Israel amplía su ayuda con Honduras y Guatemala tras los huracanes de las últimas semanas

Un innovador tratamiento con células madre desarrollado por un hospital israelí benefició a pacientes con esclerosis múltiple progresiva.

Los resultados del ensayo realizado por el Centro Médico Hadassah de Jerusalén y NeuroGénesis se publicaron en la revista Brain de la Universidad de Oxford. El tratamiento detuvo el avance de la enfermedad e incluso la revirtió, informó The Jerusalem Post.

La esclerosis múltiple (EM) es una enfermedad autoinmune que afecta a más de 2.3 millones de personas en el mundo. Causa daños en la mielina, la cubierta que protege los nervios, y promueve la transmisión de los impulsos nerviosos, así como en las células del sistema nervioso central, lo que conduce a una discapacidad neurológica.

Aquellas personas con EM experimentan hormigueo en las extremidades o entumecimiento. Además, pueden tener problemas para caminar y usar sus manos. Con el tiempo pueden incluso quedar paralizadas o tener problemas visuales. No se conoce una cura hasta la fecha. Los tratamientos existentes sólo reducen la incidencia de las recaídas o retrasan ligeramente el avance de la enfermedad.

El desarrollo del hospital israelí, conocido como NG-01, utiliza una “subpoblación autóloga patentada de células madre mesenquimales”. Es decir, células derivadas de la médula ósea de pacientes con EM, lo que asegura que no haya ningún elemento de rechazo. Las células se inyectan en la médula espinal de los pacientes y viajan al sitio de la lesión para crear un “ecosistema de reparación”.

El procedimiento es relativamente sencillo y toma unos 20 minutos bajo anestesia local. El paciente, a su vez, pasa un par de horas en observación antes de irse a casa.

Casi el 60% no mostró evidencias de actividad de la enfermedad durante todo el período de tratamiento. Por lo tanto, hay una disminución de más del 80% en el avance de la enfermedad.

Alrededor del 20% de los pacientes tratados con células madre mostró una mejoría después de la primera inyección. La enfermedad se detuvo en el 73% de los pacientes después de seis meses.

Y, por otra parte, los pacientes mejoraron su habilidad para caminar y la destreza de sus manos, aumentaron su potencia muscular y las habilidades neurológicas cognitivas. Una resonancia magnética funcional también mostró que había una mejoría en la función motora.

“Este ensayo proporciona resultados alentadores y sugiere un nuevo enfoque que puede frenar el avance de la enfermedad. Induce una mejoría y promueve los mecanismos de reparación en la EM progresiva”, manifestó el profesor Dimitrios Karussis de Hadassah, director del estudio.

El ensayo de fase 2 involucró a 48 pacientes y duró tres años. Sin embargo, unos 140 recibieron el tratamiento durante un ensayo de fase 1 en Hadassah.

En ninguno de los estudios se produjeron efectos secundarios graves relacionados con el tratamiento. Actualmente, los resultados son a corto plazo y requieren un tratamiento continuo para seguir siendo eficaces.

Karussis agregó: “Debemos ser cautelosos al interpretar los efectos positivos de los estudios de tamaño medio. Se requieren ensayos a gran escala para confirmar estos hallazgos. Por otro lado, cuando vemos tales mejoras neurológicas en pacientes con enfermedad activa y progresiva, estos hallazgos son ciertamente muy fuertes

NeuroGenesis y Hadassah compartieron los datos de sus primeros ensayos con la Administración de Alimentos y Medicamentos de Estados Unidos. A continuación, realizarán un ensayo multicéntrico de fase 3 en EE.UU., Europa e Israel. Luego iniciarán el proceso de solicitud para su aprobación de dos a cinco años más.

 

Vía The Jerusalem Post / Enlace Judío

42 COMENTARIOS

  1. Thank you, I’ve recently been looking for information approximately this subject for a while and yours is
    the best I’ve came upon till now. However, what about the conclusion?
    Are you sure in regards to the source?

  2. I am really impressed with your writing skills as well as with the layout
    on your weblog. Is this a paid theme or did you customize it
    yourself? Anyway keep up the excellent quality writing, it’s rare to see a great blog like this one
    nowadays.

  3. An interesting discussion is worth comment. There’s no doubt that that you need to publish more about this subject, it might not be a taboo subject but generally folks don’t discuss such subjects.
    To the next! Kind regards!!

  4. I’m curious to find out what blog system you are using? I’m having some minor security problems with my latest website and I’d like to find something more
    secure. Do you have any suggestions?

  5. Hello there! I know this is kinda off topic but I was wondering which blog platform are you using for this website?
    I’m getting fed up of WordPress because I’ve had issues with hackers and I’m looking at alternatives for another platform.
    I would be great if you could point me in the direction of a good platform.

  6. With havin so much content and articles do you ever run into any issues of plagorism or copyright violation? My site has a lot of unique content I’ve either authored myself or outsourced
    but it appears a lot of it is popping it up all over the internet without my
    authorization. Do you know any techniques to help protect against content
    from being ripped off? I’d really appreciate it.

  7. This is a topic which is near to my heart… Best wishes!
    Exactly where are your contact details though? games ps4 allenferguson games ps4

  8. Hi there! Would you mind if I share your
    blog with my zynga group? There’s a lot of folks that I think would really enjoy your content.
    Please let me know. Thanks

  9. I was recommended this website by my cousin. I’m not sure whether this post is written by him
    as no one else know such detailed about my trouble. You
    are wonderful! Thanks!

  10. My partner and I absolutely love your blog and find many
    of your post’s to be exactly I’m looking for. Do you offer guest writers to write content in your case?
    I wouldn’t mind writing a post or elaborating on a lot of the subjects you write regarding here.
    Again, awesome weblog!

  11. My programmer is trying to persuade me to move to .net from PHP.
    I have always disliked the idea because of the costs. But he’s tryiong none the less.
    I’ve been using Movable-type on a number of websites for about
    a year and am worried about switching to another platform.
    I have heard fantastic things about blogengine.net. Is there a way I can transfer all my wordpress content into it?
    Any kind of help would be really appreciated!
    0mniartist asmr

  12. This is very interesting, You are an excessively skilled blogger.
    I’ve joined your rss feed and look ahead to in quest
    of more of your magnificent post. Additionally, I have shared
    your web site in my social networks

  13. Hey just wanted to give you a quick heads up.
    The words in your article seem to be running off the screen in Firefox.
    I’m not sure if this is a format issue or something to do with internet browser compatibility but I thought I’d post to let you know.

    The layout look great though! Hope you get the problem fixed soon. Kudos

  14. I have been exploring for a bit for any high-quality articles or weblog posts in this kind of house .
    Exploring in Yahoo I at last stumbled upon this website.
    Reading this info So i’m glad to express that I’ve a very just right uncanny feeling I
    came upon just what I needed. I so much no doubt will make sure to don?t forget this website and provides it a glance regularly.

  15. I’m really impressed with your writing skills as well as with the layout in your
    weblog. Is that this a paid theme or did you customize it yourself?

    Anyway keep up the nice quality writing, it is uncommon to peer a nice blog like this one these days..

  16. Remarkable things here. I am very satisfied to peer your article.
    Thank you so much and I’m taking a look ahead to touch you.
    Will you please drop me a e-mail?

  17. Every weekend i used to pay a quick visit this web site, as i wish for enjoyment,
    since this this site conations actually good funny stuff too.

  18. Spot on with this write-up, I really believe this amazing site
    needs much more attention. I’ll probably be back again to read through more, thanks for the information!

  19. Thanks on your marvelous posting! I certainly enjoyed reading it, you will
    be a great author. I will be sure to bookmark your blog and will come back very soon. I want to encourage that you continue your great posts, have a nice
    afternoon!

  20. Excellent blog here! Also your site loads
    up fast! What host are you using? Can I get your affiliate link to
    your host? I wish my web site loaded up as fast as yours lol

  21. scoliosis
    Hey there would you mind letting me know which hosting company you’re using?
    I’ve loaded your blog in 3 completely different web browsers and I must say this
    blog loads a lot faster then most. Can you recommend a good internet hosting provider at
    a fair price? Thank you, I appreciate it! scoliosis

  22. scoliosis
    Its not my first time to pay a quick visit this website, i am browsing this website dailly and obtain pleasant
    facts from here every day. scoliosis

  23. scoliosis
    you are truly a excellent webmaster. The site loading velocity is amazing.
    It seems that you are doing any unique trick. Furthermore, The
    contents are masterpiece. you have done a fantastic job in this
    topic! scoliosis

  24. Hi there to every body, it’s my first go to see of this webpage; this web site consists
    of awesome and genuinely good information in support of visitors.

  25. Please let me know if you’re looking for a author for your blog.

    You have some really good articles and I think I would be a good asset.
    If you ever want to take some of the load off, I’d really like to write some content for your blog in exchange for a
    link back to mine. Please blast me an email if interested.
    Many thanks!

  26. I’m not sure why but this blog is loading
    incredibly slow for me. Is anyone else having this problem or is
    it a issue on my end? I’ll check back later and see if the problem still exists.

  27. I blog often and I truly thank you for your information. Your article has really peaked my interest.
    I will take a note of your website and keep checking
    for new details about once per week. I opted in for your Feed too.

  28. We’re a group of volunteers and opening a new scheme in our community.

    Your site provided us with valuable information to work on. You have done an impressive job and our entire community will
    be grateful to you.

DEJAR UN COMENTARIO

Please enter your comment!
Please enter your name here